FORMULATION OF NANOEMULSIONS FOR THE ENHANCEMENT OF BIOAVAILABILITY OF SOME DRUGS

Abstract

Medical or non-surgical treatment of most common eye problems involves oral as well as the topical eye-drop instillation of solutions or suspensions and topical application of eye ointments or gels among which the eye drops are generally the preferred means as they are easy to prepare and sterilize for the formulator and convenient to use for the patients. However, the drawbacks associated with these conventional eye drops such as the poor drug bioavailability and short residence time in tears result in several daily administrations to accomplish the preferred therapeutic effects, dropping the patient compliance and sometimes serious systemic side effects. Furthermore, physiology, anatomy, and biochemistry of eyes act as major barriers for drug delivery to the ocular environment. Thus it requires developing new dosage forms for effective treatment of various eye problems.